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Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants

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Dayan Goodenow, who has done very exciting work, which is why we wanted to talk with him and actually an exciting recent trial on Alzheimers disease

3.11 Intrachain and interchain disulfide bonds of RBD (319-541)-His6 detected with ESI-MS The RBD (319-541)-His6 monomer contains nine cysteine residues, with eight of them forming four intramolecular disulfide bonds (Supplementary Figure S1B)

14 Constraints of existing evidence Despite promising preclinical and early clinical findings, several limitations constrain the translation of apigenin and ellagic acid into mainstream PCOS therapy

But not by much